Randomized Double-Blinded Clinical Trial of Oxytocin Bolus versus Infusion in Elective Cesarean (INBOX Trial)
Authors' conclusion
There was no statistically significant difference in the frequency of achieving adequate uterine tone at 2 minutes between oxytocin given by infusion or bolus.
Study context
- Population
- Patients undergoing elective cesarean delivery under spinal anesthesia115 analysable
- Participants
- 121 patients
- Comparison
- Oxytocin bolus vs infusion after cord clamping
- Bolusn = 60
- Infusionn = 55reference
- Primary endpoint
- Adequate uterine tone
- Follow-up
- 2 minutes
Methodological detailsdouble-blinded, 114/115 received oxytocin per protocol
- Double-blinded
- 114/115 received oxytocin per protocol
Primary result
As reported in the abstract
P = 0.483
Secondary outcomes
Median, mL
| Outcome | Bolus | Infusion | Hodges-Lehmann estimate (mL) (95% CI) | P value | |
|---|---|---|---|---|---|
| Blood loss | 558 (IQR 429–733) | 687 (IQR 480–826) | 82 (2–168) | P = 0.0438 | |
| −1000100200Difference, mL (linear scale) |
Median
| Outcome | Bolus | Infusion | P value |
|---|---|---|---|
| Patient satisfaction score | 10 (IQR 10–10) | 10 (IQR 10–10) | P = 0.495 |
Safety
Phenylephrine dosage, PPH, nausea, additional uterotonic use
- Similar between groups
- all P > .28
Hypotension, phenylephrine use
- Similar between groups
Original publication
Randomized Double-Blinded Clinical Trial of Oxytocin Bolus versus Infusion in Elective Cesarean (INBOX Trial). Anesth Analg. Published 2 June 2026. doi:10.
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