A Randomized, Controlled Trial of Palonosetron Versus Ondansetron for Nausea, Vomiting, and Pruritus in Cesarean Delivery with Intrathecal Morphine
Authors' conclusion
Palonosetron effectively prevents intrathecal morphine-induced PONV and pruritus during cesarean delivery. However, the efficacy of palonosetron is not significantly different from that of ondansetron.
Study context
- Population
- Parturients undergoing cesarean delivery under spinal anesthesia with intrathecal morphine297 completed
- Participants
- 300 participants
- Comparison
- P vs O vs N
- Primary endpoint
- Incidence of postoperative nausea and vomiting (PONV) and pruritus
- Follow-up
- 48 hours
Methodological details3-arm, saline-controlled
- 3-arm
- Saline-controlled
Original publication
A Randomized, Controlled Trial of Palonosetron Versus Ondansetron for Nausea, Vomiting, and Pruritus in Cesarean Delivery with Intrathecal Morphine. Anesth Analg. Published 30 October 2024. doi:10.
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