Ondansetron for the Prevention of Pruritus in Women Undergoing Cesarean Delivery With Intrathecal Opioid: A Systematic Review and Meta-Analysis
Pooled resultResult — go to the resultRelative risk 0.81 95% CI 0.71–0.92Authors' conclusion
This systematic review has demonstrated a significant reduction in the incidence of pruritus following the use of ondansetron.
Study context
- Population
- Women undergoing cesarean delivery under spinal anesthesia with intrathecal opioid (morphine, fentanyl, sufentanil)
- Participants
- 2,586 women · 23 RCTs
- Comparison
- Ondansetron vs placebo
- Ondansetronn = 1,219
- Placebon = 1,030reference
- Outcome
- Presence of pruritus
Methodological detailsrandom-effects model, trial sequential analysis, sensitivity and subgroup analyses, Overall Grading of Recommendations Assessment, Development, and Evaluation (GRADE) quality of evidence low
- Random-effects model
- Trial sequential analysis
- Sensitivity and subgroup analyses
- Overall GRADE quality of evidence low
Pooled result
As reported in the abstract
Relative risk
0.81
95% CI 0.71–0.92
Ondansetron vs Placebo
RR 0.81 (95% CI 0.71–0.92)
Further pooled results
Time to onset of pruritus
- No significant difference in pruritus onset between the groups
- 17.54 minutes (MD; 95% CI, −2.18 to 37.26)
- I 2 = 83%
Original publication
Ondansetron for the Prevention of Pruritus in Women Undergoing Cesarean Delivery With Intrathecal Opioid: A Systematic Review and Meta-Analysis. Anesth Analg. Published 11 May 2023. doi:10.
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