Airway management

A temporal deep learning algorithm for prediction of extubation failures in critical care patients

J Clin Monit ComputPublished Prediction model development and validation study

Authors' conclusion

Furthermore, it demonstrated an advantage over SBT procedures in promptly identifying patients ready for extubation.

Study context

Population
ICU patients undergoing extubation (planned post-extubation NIV or tracheostomy excluded); MIMIC-III and LOCAL-Ext datasetsMIMIC-III 5,895
Comparison
TrAcE vs other models; TrAcE extubation timing vs spontaneous breathing test (SBT)
Outcome
Prediction of extubation failure (AUROC, AUPRC)
Methodological detailsdeep learning (Transformer-based, temporal fusion), external test dataset, explainable (Captum occlusion)
  • Deep learning (Transformer-based, temporal fusion)
  • External test dataset
  • Explainable (Captum occlusion)

Performance

As reported in the abstract

Extubation failure prediction
Test or modelAUROC, validation (95% CI 0.808-0.838)AUROC, testing (95% CI 0.836-0.881)AUPRC, validationAUPRC, testing
TrAcE0.8230.8590.7340.757

TrAcE

AUROC, validation (95% CI 0.808-0.838)0.823
AUROC, testing (95% CI 0.836-0.881)0.859
AUPRC, validation0.734
AUPRC, testing0.757

Further findings

OutcomeTrAcESBTP value
Days to suitable extubation identified (LOCAL-Ext)TrAcE identified suitable extubation days earlier4.32 (IQR 0–20)5.65 (IQR 0–23)P < 0.01

Original publication

A temporal deep learning algorithm for prediction of extubation failures in critical care patients. J Clin Monit Comput. Published 7 May 2026. doi:10.1007/s10877-026-01439-7

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