Effect of the extubation predictive score (ExPreS) on reintubation in the ICU: a randomized controlled trial
Authors' conclusion
In this randomized controlled trial, use of the Extubation Predictive Score (ExPreS) was associated with numerically lower rates of reintubation within 48 h compared with standard care, although the primary intention-to-treat analysis did not reach statistical significance.
Study context
- Population
- Adults ventilated ≥ 24 h who passed an spontaneous breathing trial (SBT), two ICUs of a Brazilian university hospital (November 2021-December 2024)randomised
- Participants
- 540 adults
- Comparison
- ExPreS-guided extubation vs standard protocol
- ExPreSn = 273
- Controln = 267reference
- Primary endpoint
- Extubation failure (reintubation within 48 h)
- Follow-up
- 48 h
Methodological detailssingle-centre, parallel-group, prospective, superiority, two ICUs
- Single-centre
- Parallel-group
- Prospective
- Superiority
- Two ICUs
Primary result
Extubation failure within 48 h
Absolute risk reduction
5.0%
P = 0.070
By group
As reported in the abstract
Secondary outcomes
Extubation failure within 48 h (per-protocol) · relative reduction 43% · per-protocol
absolute risk reduction 5.6% · P = 0.042
Extubation failure excluding airway obstruction (post-hoc) · post-hoc analysis
P = 0.011
Duration of mechanical ventilation, ICU LOS, ICU mortality
- No differences observed
Original publication
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