Perioperative medicine & outcomes
Ability of the integrated pulmonary index to predict impending respiratory events in the early postoperative period
Authors' conclusion
A low IPI was 75.6% sensitive for early detection (within 2-15 min) prior to respiratory events but did not achieve our preset threshold of 80% for success.
Study context
- Population
- Adults after GA, monitored with Capnostream-20p for up to 2 h in the recovery room802 events
- Participants
- 358 adults
- Outcome
- Sensitivity for early detection: ≥80% of respiratory events predicted by ≥2 consecutive low IPI (≤ 7) values 2-15 min before the event
- Follow-up
- 2-15 min before an event
Methodological detailsinvestigator-initiated, blinded to integrated pulmonary index (IPI) values, primary endpoint defined a priori
- Investigator-initiated
- Blinded to IPI values
- Primary endpoint defined a priori
Performance
As reported in the abstract
Early detection success (≥2 consecutive low IPI [≤7] values within 2-15 min before an event)
Events detected early, of 802 total events
606
Sensitivity for early detection
75.6%
95% CI 72.6–78.5%
Shortfall vs 80% sensitivity goal (p = 0.0016)
4.4%
Further findings
Total detection success (early or late)
- Events detected early or late, of 802 total events
- 653
- Sensitivity for total success
- 81.4% (95% CI 78.7-84.1%)
- Difference from 90% on-time sensitivity goal (p < 0.0001)
- 8.6%
Original publication
Ability of the integrated pulmonary index to predict impending respiratory events in the early postoperative period. Perioper Med (Lond). Published 17 July 2023. doi:10.
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