Cardiac arrest & resuscitation

Accuracy of EEG Slow Wave Activity in Predicting Favorable Outcome in Patients With Hypoxic Brain Injury—A Protocol for a Substudy of the STEPCARE Trial

Acta Anaesthesiol ScandPublished Protocol for a prespecified prospective diagnostic accuracy substudy of the STEPCARE randomised trial

Study context

Population
Adult out-of-hospital cardiac arrest (OHCA) patients in the STEPCARE trialplanned recruitment 300
Planned comparison
C-Trend Index vs blinded retrospective visual analysis of cEEG
Primary endpoint
Accuracy (proportion of correct predictions of all predictions) in predicting favorable functional outcome (modified Rankin Scale 0-3); non-inferiority limit 2%
Follow-up
6 months after cardiac arrest
Methodological detailspre-planned, non-inferiority, factorial parent trial, cEEG recorded starting as early as possible after ICU admission, Will assess whether the sedation intervention of STEPCARE modifies the performance of EEG-based predictors
  • Pre-planned
  • Non-inferiority
  • Factorial parent trial
  • cEEG recorded starting as early as possible after ICU admission
  • Will assess whether the sedation intervention of STEPCARE modifies the performance of EEG-based predictors

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Accuracy of EEG Slow Wave Activity in Predicting Favorable Outcome in Patients With Hypoxic Brain Injury—A Protocol for a Substudy of the STEPCARE Trial. Acta Anaesthesiol Scand. Published 17 September 2025. doi:10.1111/aas.70126

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