Cardiac arrest & resuscitation
Early Prediction of Neurological Outcome After Cardiac Arrest‐Rationale and Design of the Prospective International Observational EARLY ‐ NEURO , a STEPCARE Substudy
Study context
- Population
- Adults sedated or still unconscious at 24 h after cardiac arrest, randomised in the STEPCARE trial
- Planned comparison
- Head computed tomography (CT) vs EEG vs Neurofilament light
- Primary endpoint
- Good or poor functional outcome by modified Rankin Scale (dichotomised 0-3 vs 4-6)
- Follow-up
- 6 months
Methodological detailsinternational, multicentre, blinded central evaluation, STARD reporting, Raters blinded to treatment allocations and patient outcomes, withdrawal of life-sustaining therapy (WLST) before 72 h after randomisation based on presumed futile neurological prognosis strongly discouraged; timepoint and reasons for WLST recorded
- International
- Multicentre
- Blinded central evaluation
- STARD reporting
- Raters blinded to treatment allocations and patient outcomes
- WLST before 72 h after randomisation based on presumed futile neurological prognosis strongly discouraged; timepoint and reasons for WLST recorded
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Early Prediction of Neurological Outcome After Cardiac Arrest‐Rationale and Design of the Prospective International Observational EARLY ‐ NEURO , a STEPCARE Substudy. Acta Anaesthesiol Scand. Published 17 April 2026. doi:10.
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