Cardiac arrest & resuscitation
Computed tomography perfusion assessment of poor neurological outcome in comatose cardiac arrest patients (CANCCAP): a prospective study
Authors' conclusion
CTP was safe and demonstrated very high specificity and positive predictive value and may be used as an additional diagnostic tool for identifying patients at high risk of in-hospital mortality.
Study context
- Population
- Newly admitted adult comatose cardiac arrest patients after of hospital cardiac arrest (OHCA) scheduled for intensive care units (ICU) admission90 analysed
- Participants
- 91 participants
- Outcome
- Prediction of in-hospital mortality by CTP
Methodological detailsblinded assessment, Treating physicians blinded to computed tomography perfusion (CTP) results; two independent neuroradiologists blinded to each other and clinical history
- Blinded assessment
- Treating physicians blinded to CTP results; two independent neuroradiologists blinded to each other and clinical history
Main finding
As reported in the abstract
Prediction of non-survivable brain injury (NSBI)
| Group | Specificity | PPV |
|---|---|---|
| CTP | 100%; 95% CI 92-100% | 100%; 95%CI 6.3-100% |
CTP
Specificity100%; 95% CI 92-100%
PPV100%; 95%CI 6.3-100%
Observational data: associations, not effects.
Further findings
In-hospital mortality (whole cohort)
- Patients with in-hospital mortality
- 42 (47%)
Factors associated with in-hospital mortality
- Non-survivors older; higher creatinine, blood urea nitrogen, blood CO2; lower pH, carbonate and heart rate
- PCI independently associated with reduced in-hospital mortality (multivariate analysis)
Inter-reader agreement for CTP (Bennet's S-score)
- Excellent agreement between the two readers
- s = 0.82-0.95
Original publication
Computed tomography perfusion assessment of poor neurological outcome in comatose cardiac arrest patients (CANCCAP): a prospective study. Crit Care. Published 23 May 2025. doi:10.
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