Cardiac arrest & resuscitation
Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study
Authors' conclusion
Standardised qualitative and quantitative assessments of CT are reliable and feasible methods to predict poor functional outcome after cardiac arrest.
Study context
- Population
- Adult unconscious patients after OHCA with routine head computed tomography (CT) > 48 h ≤ 7 days post-arrest75% poor outcome
- Participants
- 140 patients
- Comparison
- Qualitative assessment vs GWR-8 vs GWR-4 vs Automated GWR
- Outcome
- Prognostic accuracy for poor functional outcome (modified Rankin Scale 4-6)
Methodological detailsprospective, international, multicentre, observational, within the TTM2 trial, raters blinded to clinical information, pre-published protocol
- Prospective
- International
- Multicentre
- Observational
- Within the TTM2 trial
- Raters blinded to clinical information
- Pre-published protocol
Performance
As reported in the abstract
Prediction of poor functional outcome (modified Rankin Scale 4-6)
| Test or model | AUC | Sensitivity (median) |
|---|---|---|
| Standardised qualitative | — not stated in the abstract | 37% |
| GWR-8 | — not stated in the abstract | 39% |
| GWR-4 | — not stated in the abstract | 30% |
| Automated GWR | 0.84 (95% CI 0.77-0.91) | 41% |
AUC
Standardised qualitative— not stated in the abstract
GWR-8— not stated in the abstract
GWR-4— not stated in the abstract
Automated GWR0.84 (95% CI 0.77-0.91)
Sensitivity (median)
Standardised qualitative37%
GWR-839%
GWR-430%
Automated GWR41%
— not stated in the abstract
- Standardised qualitative assessment and all GWR models: specificity
- 100% (95% CI 90-100)
Original publication
Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study. Intensive Care Med. Published 20 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →