Neuroanesthesia & neurocritical care
Acute pulmonary edema after subarachnoid hemorrhage: risk factors and comorbidities—an analysis of a nationwide database from the United States
Authors' conclusion
APE after SAH is associated with increased complicated hospital course.
Study context
- Population
- Adult inpatients with a primary diagnosis of non-traumatic subarachnoid hemorrhage (SAH), US National Inpatient Sample 2016 to 2021
- Participants
- 42,141 inpatients
- Exposure
- SAH with acute pulmonary edema (APE) vs without APE
- APEn = 960
- Outcome
- Incidence of and independent risk factors for APE
Methodological detailsnationwide database (National Inpatient Sample), multivariable analysis
- Nationwide database (National Inpatient Sample)
- Multivariable analysis
Main finding
As reported in the abstract
Incidence of APE and independent risk factors (multivariable)
APE
2.3%
960
Adjusted odds ratio (95% CI)P value
Coagulopathies
1.57(1.31–1.89)
P < 0.001Fluid and electrolyte disorders
2.54(2.13–3.03)
P < 0.001Liver disease
1.37(1.07–1.76)
P = 0.013Obesity
1.47(1.19–1.81)
P = 0.003Pulmonary circulatory disorder
1.72(1.31–2.26)
P = 0.001Weight loss
1.67(1.36–2.04)
P < 0.001Observational data: associations, not effects.
Further findings
Elixhauser comorbidity index ≥ 3
P < 0.001
Mortality
P < 0.001
| Outcome | APE | No APE | P value |
|---|---|---|---|
| LOS | 20.0 ± 18.9 days | 11.6 ± 14.3 | P < 0.001 |
| Total costs | $503,671.3 ± 647,729.9 | $238,724.6 ± 328,062.1 | P < 0.001 |
| Days from admission to first procedure | 3.5 ± 7.3 | 1.9 ± 4.9 | P < 0.001 |
Original publication
Acute pulmonary edema after subarachnoid hemorrhage: risk factors and comorbidities—an analysis of a nationwide database from the United States. J Intensive Care. Published 13 May 2025. doi:10.
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