Neuroanaesthesia & neurocritical care
Neurological outcomes after out-of-hospital cardiac arrest due to aneurysmal subarachnoid hemorrhage: a multicenter cohort study
Authors' conclusion
OHCA-aSAH carries a dismal prognosis, with < 5% achieving favorable neurological recovery.
Study context
- Population
- Adults admitted alive after out-of-hospital cardiac arrest (OHCA) due to aneurysmal SAH (OHCA-aSAH), 12 French neuro-ICUs, 2014–2024of 15,907 SAH admissions
- Participants
- 164 adults
- Outcome
- Neurological outcome (modified Rankin Scale, mRS); favorable outcome mRS ≤ 3
- Follow-up
- 6 months
Methodological detailsmulticentre, Firth penalized logistic regression
- Multicentre
- Firth penalized logistic regression
Main finding
As reported in the abstract
Neurological outcome at 6 months (mRS)
Favorable outcome (mRS ≤ 3)
8
4.9%
Poor outcome (mRS ≥ 4)
156
95.1%
Deaths (mRS 6)
154
Observational data: associations, not effects.
Further findings
Predictors of favorable outcome
- Shorter low-flow duration, less epinephrine use and fewer pupillary abnormalities among survivors, but no independent statistical association confirmed; penalized regression identified no independent predictors of good outcome
Pre-hospital antiplatelet or anticoagulant therapy (subgroup)
- All patients on pre-hospital antiplatelet or anticoagulant therapy had poor outcome
- n = 14, 8.7%
ICU management in survivors
- External ventricular drainage, ICP monitoring and endovascular aneurysm treatment more frequent, ICU and hospital LOS longer, in survivors
Progression to brain death · within 1 [1-2] day
- Progressed to brain death
- 108 (65.8%)
- Pupillary abnormalities and epinephrine use associated with progression toward brain death
Original publication
Neurological outcomes after out-of-hospital cardiac arrest due to aneurysmal subarachnoid hemorrhage: a multicenter cohort study. Crit Care. Published 10 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →