Neuroanesthesia & neurocritical care
Association of Fluid Balance and Hemoglobin Decline With Neurological Outcome After Aneurysmal Subarachnoid Hemorrhage*
Authors' conclusion
Increased fluid balance influences hemoglobin decline through hemodilution. Fluid overload, rather than a slight decrease in hemoglobin levels, appears to be the primary factor contributing to poor outcomes in aSAH patients.
Study context
- Population
- Patients with aneurysmal SAH treated in ICUs at 19 tertiary hospitals in Germany, Switzerland and Canada237 analysed
- Participants
- 287 patients
- Comparison
- Fluid balance and Hb decline vs neurological outcome
- Primary endpoint
- Neurological outcome on modified Rankin Scale (mRS) (unfavorable mRS > 2) and secondary infarctions
- Follow-up
- 6 months
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Unfavorable outcome (mRS > 2)
Threshold for unfavorable outcome: Hb (first 8 days)
10.4 g/dL
Threshold for unfavorable outcome: cumulative fluid balance (first 8 days)
4894 mL
Further findings
Secondary infarctions
- Fluid balance but not Hb related to secondary infarctions; significant after inverse probability of treatment weighting
Transfusion
- Transfusion associated with unfavorable outcomes
Original publication
Association of Fluid Balance and Hemoglobin Decline With Neurological Outcome After Aneurysmal Subarachnoid Hemorrhage*. Crit Care Med. Published 21 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →