Addition of Liposomal Bupivacaine to Standard Bupivacaine versus Standard Bupivacaine Alone in the Supraclavicular Brachial Plexus Block: A Randomized Controlled Trial
Authors' conclusion
Liposomal bupivacaine given via supraclavicular brachial plexus block reduced pain at rest in the early postoperative period.
Study context
- Population
- Patients undergoing distal radial fracture fixation under RA with supraclavicular brachial plexus block
- Participants
- 80 patients
- Comparison
- Liposomal bupivacaine vs Standard bupivacaine
- Liposomal bupivacainen = 40
- Standard bupivacainen = 40reference
- Primary endpoint
- Weighted AUC NRS pain score at rest
- Follow-up
- First 48 h after surgery
Methodological detailspatient- and outcome assessor-blinded
- Patient- and outcome assessor-blinded
Primary result
As reported in the abstract
first 48 h
Liposomal bupivacaine
0.6
Standard bupivacaine
1.4
P < 0.001
Secondary outcomes
Weighted AUC pain score with movement · first 48 h
- Weighted AUC pain with movement, 2.3 vs. 3.7 (in the order liposomal vs standard bupivacaine, as for the primary outcome)
- adjusted P < 0.001
Overall benefit with analgesia score · first 48 h
- Overall benefit with analgesia score, 1.1 vs. 1.7 (in the order liposomal vs standard bupivacaine, as for the primary outcome)
- adjusted P = 0.020
NRS pain score at rest · POD 1
- NRS pain at rest on POD 1, 0.5 vs. 1.9 (in the order liposomal vs standard bupivacaine, as for the primary outcome)
- adjusted P < 0.001
NRS pain score with movement · POD 1
- NRS pain with movement on POD 1, 2.7 vs. 4.9 (in the order liposomal vs standard bupivacaine, as for the primary outcome)
- adjusted P < 0.001
NRS pain scores · POD 2, 3 and 4
- Differences did not reach statistical significance
Other secondary outcomes, including sensory function
- No statistically significant difference between treatment groups
Original publication
Addition of Liposomal Bupivacaine to Standard Bupivacaine versus Standard Bupivacaine Alone in the Supraclavicular Brachial Plexus Block: A Randomized Controlled Trial. Anesthesiology. Published 2 May 2024. doi:10.
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