Adverse events as key risk factors for in-hospital mortality in intensive care units
Authors' conclusion
The presence of AEs was associated with a two-fold higher risk of in-hospital mortality. Among the identified AEs, HAIs were the most frequent and had the highest mortality.
Study context
- Population
- Critically ill ICU patients in 26 hospitals, Community of Madrid, single day in May 2019
- Participants
- 458 patients · 26 hospitals
- Exposure
- Patients with adverse events (AEs) vs without AEs
- AEsn = 125
- Outcome
- Prevalence of AEs (Harvard Medical Practice Study (HMPS) methodology)
Methodological detailsmulticentre, observational, single-day, Harvard Medical Practice Study methodology
- Multicentre
- Observational
- Single-day
- Harvard Medical Practice Study methodology
Main finding
As reported in the abstract
Patients with ≥1 AE
AEs
27.3%
125
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| In-hospital mortalityAdjusted for potential confounders | 2.15 (1.10–4.25) | |
| 0.20.5125Odds ratio (log scale) |
Factors associated with AEs
- Pressure ulcer, hypoalbuminemia, mechanical ventilation, central venous catheter, surgical intervention and sensory deficit associated with AEs
Health care-associated infections among AEs
- Proportion of AEs that were HAIs
- 44.6%
Original publication
Adverse events as key risk factors for in-hospital mortality in intensive care units. Crit Care. Published 7 March 2026. doi:10.
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