Age and associated outcomes among patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory failure: analysis of the Extracorporeal Life Support Organization registry
Authors' conclusion
Among patients receiving VV-ECMO for acute respiratory failure, increasing age is significantly associated with poorer outcomes, and this association emerges as early as 30 years of age.
Study context
- Population
- Adults (≥ 18 years) receiving VV-ECMO for acute respiratory failure, Extracorporeal Life Support Organization registry, 144 centres, 2017–2022
- Participants
- 27,811 adults · 144 centres
- Exposure
- Age brackets 30-39, 40-49, 50-59, 60-69, 70-79 and ≥ 80 vs 18-29 years
- Outcome
- Hospital mortality
Methodological detailsmulticentre registry, Bayesian analyses
- Multicentre registry
- Bayesian analyses
Main finding
As reported in the abstract
Each group vs 18-29Odds ratio (95% CrI)
30-39
1.17(1.06–1.31)
40-49
1.65(1.49–1.82)
50-59
2.39(2.16–2.61)
60-69
3.29(2.97–3.67)
70-79
4.57(3.90–5.37)
≥ 80
8.08(4.85–13.74)
- Overall hospital deaths
- 11,533 (41.5%)
Observational data: associations, not effects.
Secondary outcomes
Composite of post-ECMO complications
- Similar results between increasing age and post-ECMO complications
Original publication
Age and associated outcomes among patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory failure: analysis of the Extracorporeal Life Support Organization registry. Intensive Care Med. Published 20 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →