ICU sedation, delirium & recovery
Age-related modification of the association between arterial blood pH and intensive care unit mortality: a nationwide retrospective observational study using the Japanese Intensive Care Patient Database (JIPAD)
Authors' conclusion
A lower arterial blood pH was associated with higher ICU mortality, and this association was modified by age.
Study context
- Population
- Adult patients (≥ 18 years) admitted to participating intensive care unit (ICUs), Japanese Intensive Care Patient Database (2018–2023)
- Participants
- 324,806 ICU admissions
- Exposure
- 18-64 years vs ≥ 65 years
- ≥ 65 yearsn = 215,880
- Outcome
- ICU mortality
Methodological detailsnationwide, multivariate Cox proportional hazard models with restricted cubic splines, stratified by institution
- Nationwide
- Multivariate Cox proportional hazard models with restricted cubic splines
- Stratified by institution
Main finding
As reported in the abstract
ICU mortality, pH 7.0 vs 7.35-7.45, by age
Adjusted hazard ratio (95% CI)
pH 7.0 (18-64 years) vs pH 7.35-7.45 (18-64 years)
3.40(3.07–3.76)
pH 7.0 (≥ 65 years) vs pH 7.35-7.45 (≥ 65 years)
4.73(4.33–5.16)
Observational data: associations, not effects.
Further findings
ICU mortality, all admissions
- ICU mortality
- 4.4%
Continuous-age modeling
- Supported age-related modification across the age spectrum
Original publication
Age-related modification of the association between arterial blood pH and intensive care unit mortality: a nationwide retrospective observational study using the Japanese Intensive Care Patient Database (JIPAD). J Intensive Care. Published 29 September 2026. doi:10.
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