Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study
Authors' conclusion
In patients with resuscitated sepsis, albumin infusion might lead to greater improvement of tissue hypoperfusion compared to saline.
Study context
- Population
- Patients with sepsis with or without shock and prolonged CRT > 3 s despite initial resuscitation13 sepsis, 37 septic shock
- Participants
- 50 patients
- Exposure
- Human serum albumin 20% 100 mL vs saline 500 mL over 15 min
- Albuminn = 29
- Salinen = 21reference
- Outcome
- CRT normalization (< 3 s)
- Follow-up
- H1
Methodological detailsbi-centric, proof-of-concept, clinician-chosen fluid (non-randomised)
- Bi-centric
- Proof-of-concept
- Clinician-chosen fluid (non-randomised)
Main finding
As reported in the abstract
Albumin
63
%
Saline
29%
P = 0.02
Observational data: associations, not effects.
Further findings
Urinary output · H4 · trended to be higher with albumin
P = 0.08
| Outcome | Albumin | Saline | P value |
|---|---|---|---|
| Decrease in fingertip CRT · H1 | - 1.0 (IQR - 0.3; - 1.5) seconds | - 0.2 (IQR - 0.1; - 1.1) seconds | P = 0.04 |
Decrease in fingertip CRT · H1
- Greater decrease in mottling score with albumin
Peripheral tissue perfusion · H4
- Beneficial effects of albumin on peripheral tissue perfusion maintained
Arterial lactate, H0 to H4
- No significant change with saline; significant decrease with albumin
- P = 0.03
Original publication
Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study. Crit Care. Published 7 February 2024. doi:10.
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