Cardiac arrest & resuscitation
Alteration in early resting‑state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study
Authors' conclusion
This study revealed that abnormal rs-fMRI BOLD signals in resuscitated patients showed complex changes, characterized by increased activity in some local brain regions and reduced activity in others. Abnormal BOLD signals were associated with neurological outcomes in resuscitated patients. The mean ALFF values of the whole brain were closely related to SjvO2 levels, and changes in the thalamic BOLD signals correlated with the N20-baseline amplitudes of SSEP responses.
Study context
- Population
- Comatose survivors early after cardiac arrest, January 2021 to January 2024
- Participants
- 31 vs 20
- Exposure
- Comatose post-CA patients vs healthy controls
- Cardiac arrest (CA)n = 31
- Healthy controlsn = 20reference
- Outcome
- Regional rs-fMRI activity (ALFF, fractional ALFF (fALFF), ReHo of blood oxygenation level-dependent (BOLD) signals) and its relationship with neurological outcome (CPC scale)
- Follow-up
- CPC at 3 months after CA
Main finding
As reported in the abstract
- Complex changes: increased activity in some local brain regions, reduced in others vs healthy controls
- P < 0.05
- Mean whole-brain amplitude of low-frequency fluctuation (ALFF) significantly greater in CA patients
- P = 0.011
Observational data: associations, not effects.
Further findings
Correlation of abnormal resting-state functional magnetic resonance imaging (rs-fMRI) clusters with cerebral performance category (CPC) score · 3 months
- ALFF cluster values in left middle and inferior temporal gyrus and regional homogeneity (ReHo) cluster values in right precentral, superior and middle frontal gyrus strongly correlated with CPC score
- P < 0.001
Correlation of mean ALFF with SjvO2 in CA patients
- Strong correlation
- r = 0.910, P < 0.001
Correlation of SSEP N20-baseline amplitude with thalamic rs-fMRI activity
- Negatively correlated
- all P < 0.001
Original publication
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