Pediatric anesthesia & critical care
Limbic pathway vulnerability associates with neurologic outcome in children after cardiac arrest
Authors' conclusion
Decreased multimodal connectivity measures of paralimbic tracts were associated with unfavorable neurologic outcome after pediatric cardiac arrest.
Study context
- Population
- Children aged 2 d-17 y after cardiac arrest with brain MRI (diffusion tensor imaging (DTI), resting state functional magnetic resonance imaging (rsfMRI)) within 2 weeks after arrestDTI n = 28
- Exposure
- Unfavorable vs favorable neurologic outcome
- Outcome
- Unfavorable neurologic outcome:
- Pediatric Cerebral Performance Category score 4-6
- Change > 1 vs baseline
- Follow-up
- 6 months after arrest
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Brain connectivity measures and unfavorable neurologic outcome
- DTI cohort (n = 28): unfavorable outcome
- 57%
- Mean, radial, axial diffusivity and fractional anisotropy (FA) in limbic tracts (right cingulum parolfactory, left cingulum parahippocampal, corpus callosum forceps major and minor) associated with unfavorable outcome
- p < 0.05
- rsfMRI cohort (n = 12): unfavorable outcome
- 67%
- Decreased functional connectivity strength (FCS) in ventromedial and dorsolateral prefrontal cortex, insula, precentral gyrus, anterior cingulate and inferior parietal lobule correlated with unfavorable outcome
- p < 0.05
Observational data: associations, not effects.
Original publication
Limbic pathway vulnerability associates with neurologic outcome in children after cardiac arrest. Resuscitation. Published 3 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →