Respiratory failure & ventilation
Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
Authors' conclusion
ARDS caused by COVID-19 is sustained by impairment of redox balance, particularly in erythrocytes. This alteration is associated with the pro-inflammatory and pro-coagulant status which characterizes severe COVID-19.
Study context
- Population
- Patients with ARDS
- Participants
- 40 vs 42
- Exposure
- COVID-19 ARDS vs non-COVID-19 ARDS
- COVID-19n = 40
- No COVID-19n = 42reference
- Outcome
- Circulating markers of redox balance in serum and erythrocytes
Main finding
As reported in the abstract
Circulating redox balance markers
- No differences in serum markers of oxidative damage between groups
- Reduced total antioxidant status and serum ceruloplasmin in COVID-19 vs No COVID-19
- Erythrocytes in COVID-19: increased lipofuscin and malondialdehyde, reduced glutathione S-transferase and glutathione reductase activity vs No COVID-19
Observational data: associations, not effects.
Further findings
Association of redox markers with severity, inflammation and coagulability (COVID-19 ARDS)
- Markers associated with Horowitz index, alveolar-to-arterial oxygen gradient, interleukin-6, interleukin-10 and D-dimer
Original publication
Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome. J Intensive Care. Published 5 July 2023. doi:10.
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