Cardiac arrest & resuscitation
Amplitude spectrum area to predict true shock-refractory ventricular fibrillation during basic life support-treated out-of-hospital cardiac arrest
Main finding · True shock-refractory VFResult — go to the resultAdjusted odds ratio 0.81 95 % CI 0.73–0.88Authors' conclusion
Lower AMSA is associated with true shock-refractory VF, a subtype associated with persistent defibrillation failure and worse long-term survival.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) with shockable presenting rhythm treated with basic life support, ECGs from automated external defibrillators, 8 cities in Italy360 pragmatic-refractory ventricular fibrillation (VF)
- Participants
- 1,646 participants
- Exposure
- Amplitude spectrum area (AMSA) in true shock-refractory VF vs refractory-recurrent VF
- Outcome
- Prediction of true shock-refractory VF by AMSA
Methodological detailsmulticentre
- Multicentre
Main finding
True shock-refractory VF
Adjusted odds ratio
0.81
95 % CI 0.73–0.88
P < 0.0001
By group
AMSA in true shock-refractory VF vs refractory-recurrent VF
aOR 0.81 (95 % CI 0.73–0.88); P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Pragmatic-refractory VF (guideline definition)
- Met definition of pragmatic-refractory VF
- 360 (22 %)
Original publication
Amplitude spectrum area to predict true shock-refractory ventricular fibrillation during basic life support-treated out-of-hospital cardiac arrest. Resuscitation. Published 27 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →