An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome
Authors' conclusion
We found an association between whole blood and the development of ARDS among trauma patients who received blood transfusions.
Study context
- Population
- Trauma patients ≥15 years in the American College of Surgeons Trauma Quality Improvement Program (TQIP) database who received at least one blood product
- Participants
- 134,863 patients
- Exposure
- Acute respiratory distress syndrome (ARDS) vs no ARDS among blood product recipients
- ARDSn = 1,927
- Outcome
- Factors associated with ARDS (multivariable model)
Methodological detailsregistry database (TQIP), multivariable model, sensitivity testing
- Registry database (TQIP)
- Multivariable model
- Sensitivity testing
Main finding
As reported in the abstract
Estimate (95% CI)
Whole blood
unit OR 1.05(1.02–1.07)
Male sex
OR 1.44(1.28–1.63)
Arrival shock index
unit OR 1.03(1.01–1.06)
Composite Injury Severity Score
unit OR 1.03(1.03–1.04)
Observational data: associations, not effects.
Further findings
Unadjusted survival to discharge
Median
| Outcome | ARDS | No ARDS |
|---|---|---|
| Composite Injury Severity Score | 30 (IQR 22–41) | 21 (IQR 11–30) |
ARDS incidence
- Diagnosed with ARDS
- 1% (1927)
Serious injuries (head/neck, thorax, abdomen, extremities)
- Head/neck: no ARDS vs ARDS
- 31% vs. 46%
- Thorax: no ARDS vs ARDS
- 51% vs. 78%
- Abdomen: no ARDS vs ARDS
- 34% vs. 48%
- Extremities: no ARDS vs ARDS
- 37% vs. 47%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome. Crit Care Med. Published 15 November 2024. doi:10.
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