Association between whole blood ratio and risk of mortality in massively transfused trauma patients: retrospective cohort study
Main finding · 24-h mortality (adjusted)Result — go to the resultAdjusted odds ratio 0.61 95% CI 0.46–0.81Authors' conclusion
The probability of mortality consistently decreased with higher WBR in trauma patients requiring massive blood transfusion.
Study context
- Population
- Trauma patients aged ≥ 18 years receiving whole blood (WB) within 4 h of hospital arrival as part of massive blood transfusion, ACS-TQIP 2020–2021eligible for analysis
- Participants
- 4,087 patients
- Exposure
- Highest vs lowest whole blood ratio quartile
- Outcome
- 24-h mortality
- Follow-up
- 24 h
Methodological detailsregistry (ACS-TQIP), multivariable logistic regression with generalized estimating equations, within-hospital clustering accounted for
- Registry (ACS-TQIP)
- Multivariable logistic regression with generalized estimating equations
- Within-hospital clustering accounted for
Main finding
24-h mortality (adjusted)
Adjusted odds ratio
0.61
95% CI 0.46–0.81
Highest WBR quartile vs Lowest WBR quartile
aOR 0.61 (95% CI 0.46–0.81)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| 30-day mortality (adjusted) | 0.58 (0.45–0.75) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Association between whole blood ratio and risk of mortality in massively transfused trauma patients: retrospective cohort study. Crit Care. Published 19 July 2024. doi:10.
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