Pediatric anesthesia & critical care
An Assessment of the Practice of Neuromuscular Blockade and the Association Between Its Prophylactic Use and Outcomes Among Postoperative Pediatric Cardiac Patients
Main findingResult — go to the resultOdds ratio 1.79 95% CI 0.23–13.93Authors' conclusion
Postoperative prophylactic neuromuscular blockade after cardiac surgery can be associated with prolonged mechanical ventilation, but has no association with MAEs among pediatric patients with congenital heart disease.
Study context
- Population
- Patients younger than 18 with congenital heart disease after cardiac surgery
- Participants
- 566 participants
- Exposure
- Prophylactic NMBA infusion vs no prophylactic NMBA infusion
- Prophylactic NMBA (pNMBA)n = 207
- Outcome
- Composite of MAEs:
- Death from any cause
- Circulatory collapse needing CPR
- Requirement for ECMO
- Follow-up
- Within 7 days after surgery
Methodological detailssingle-centre, tertiary teaching hospital
- Single-centre
- Tertiary teaching hospital
Main finding
As reported in the abstract
Odds ratio
1.79
95% CI 0.23–13.93
P = 0.58
By group
pNMBA vs non-pNMBA
OR 1.79 (95% CI 0.23–13.93); P = 0.58
- Major adverse events (MAEs) overall
- 13 patients (2.3%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (days) | P value |
|---|---|---|
| Total duration of mechanical ventilation · first 30 days after surgeryMultivariate regression; prolonged with pNMBA | 3.85 | P < 0.001 |
Original publication
An Assessment of the Practice of Neuromuscular Blockade and the Association Between Its Prophylactic Use and Outcomes Among Postoperative Pediatric Cardiac Patients. J Cardiothorac Vasc Anesth. Published 23 February 2023. doi:10.
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