Pediatric anesthesia & critical care
Effect of Dexmedetomidine on Rocuronium‐Induced Neuromuscular Blockade and Intubation Condition in Children: A Randomized Controlled Trial
Authors' conclusion
Our results showed that dexmedetomidine infusion before induction of anesthesia with propofol reduced the onset time of rocuronium and provided a better hemodynamic profile during endotracheal intubation in children.
Study context
- Population
- Children aged 4–12 years undergoing elective surgery, anaesthesia induced with propofol and rocuronium
- Participants
- 60 children
- Comparison
- D vs P
- Dn = 30
- Pn = 30reference
- Primary endpoint
- Onset time of rocuronium (time to TOF = 0 from end of rocuronium infusion)
Primary result
As reported in the abstract
Onset time of rocuronium
P = 0.021
Further findings
Time for BIS < 60 · unaffected by dexmedetomidine
P = 0.772
Haemodynamics at intubation
- SBP, diastolic BP, MAP and heart rate significantly lower in group D (more stable haemodynamic response)
Intubation attempts
- No difference between groups
Safety
Adverse effects
- No difference between groups
Original publication
Effect of Dexmedetomidine on Rocuronium‐Induced Neuromuscular Blockade and Intubation Condition in Children: A Randomized Controlled Trial. Paediatr Anaesth. Published 20 December 2025. doi:10.
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