Pediatric anesthesia & critical care
Comparison of Different Neostigmine Doses for Reversal of Cisatracurium‐Induced Neuromuscular Block in Children Under Total Intravenous Anesthesia: A Randomized Controlled Trial
Authors' conclusion
At TOF count of 3, neostigmine 10-30 μg/kg shortened reversal compared with no reversal, but doses above 10 μg/kg conferred no additional benefit.
Study context
- Population
- Children 2–10 years, ASA I–II, undergoing tonsillectomy under TIVA with cisatracurium-induced NMB118 analysed
- Participants
- 120 children
- Comparison
- Neostigmine 10, 20 or 30 μg/kg vs 0 μg/kg at TOF count of 3
- Primary endpoint
- Time from TOF count of 3 to full reversal (TOFR = 1.0), quantitative acceleromyography
Methodological detailsprospective, double-blind, parallel-group, superiority
- Prospective
- Double-blind
- Parallel-group
- Superiority
Primary result
As reported in the abstract
Time to full reversal
P = 0.33
Secondary outcomes
- Full reversal (TOF ratio 1.0) within 10 min — 0 μg/kg
- 10.7%
Safety
Adverse events (exclusively transient bradycardia and tachycardia)
- Adverse events, all patients
- 10 of 118
- No differences among groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of Different Neostigmine Doses for Reversal of Cisatracurium‐Induced Neuromuscular Block in Children Under Total Intravenous Anesthesia: A Randomized Controlled Trial. Paediatr Anaesth. Published 8 May 2026. doi:10.
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