Pediatric anesthesia & critical care
Ultrasonographic assessment of sugammadex-enhanced early recovery of diaphragmatic function in children: A randomised double-blind controlled trial
Authors' conclusion
Compared to neostigmine, sugammadex accelerates diaphragmatic recovery immediately after extubation; however, this early recovery does not significantly reduce the incidence of postoperative atelectasis.
Study context
- Population
- Children aged 2 to 7 years, NMB reversal at TOF count 4 (TOFR < 0.9), Seoul National University Children's Hospital, Republic of Korea
- Participants
- 73 children
- Comparison
- Sugammadex vs neostigmine for NMB reversal
- Sugammadexn = 36
- Neostigminen = 37reference
- Primary endpoint
- Diaphragmatic excursion ratio (DE T1 /DE T0 ) by ultrasound
- Follow-up
- T1 (before PACU admission)
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
DE T1 /DE T0 · T1
Neostigmine
0.91
± 0.19
Sugammadex
1.02
± 0.24
P = 0.034
Secondary outcomes
| Outcome | Sugammadex | Neostigmine | P value |
|---|---|---|---|
| TF T1 /TF T0Significantly higher with sugammadex | 1.15 ± 0.49 | 0.93 ± 0.39 | P = 0.041 |
Diaphragmatic excursion (DE) T2 /DE T0 and thickening fraction (TF) T2 /TF T0 · T2 (30 min after postanaesthesia care unit (PACU) admission)
- No significant intergroup differences
Atelectasis score and incidence of significant atelectasis (lung ultrasonography) · T1 and T2
- Comparable between the groups
Original publication
Ultrasonographic assessment of sugammadex-enhanced early recovery of diaphragmatic function in children: A randomised double-blind controlled trial. Eur J Anaesthesiol. Published 7 July 2025. doi:10.
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