Pediatric anesthesia & critical care
Comparison of postoperative oxygenation in children receiving sugammadex versus neostigmine for reversal of neuromuscular blockade: a retrospective cohort study
Main finding · Mean SpO2/FIO2 ratio, first postoperative hourResult — go to the resultDifference in means −6.2 95% CI −12.8 to 0.41Authors' conclusion
In this retrospective cohort study, postoperative oxygenation was similar in children after reversal of neuromuscular blockade with sugammadex versus neostigmine.
Study context
- Population
- Children aged 2–17 yr undergoing noncardiac surgery with GA, Cleveland Clinic Main Campus, January 2017–April 2023
- Participants
- 3,523 cases
- Exposure
- Sugammadex vs neostigmine for reversal of NMB
- Sugammadexn = 430
- Neostigminen = 3,081reference
- Outcome
- Postoperative oxygenation: mean SpO2/FIO2 ratio during the initial hour in the PACU
- Follow-up
- First postoperative hour
Methodological detailsinverse probability of treatment weighting, single-centre
- Inverse probability of treatment weighting
- Single-centre
Main finding
Mean SpO2/FIO2 ratio, first postoperative hour
Difference in means
−6.2
95% CI −12.8 to 0.41
P = 0.07
By group
Sugammadex
403
median · IQR 356–464
Neostigmine
408
median · IQR 357–462
Sugammadex vs Neostigmine
difference in means −6.2 (95% CI −12.8 to 0.41); P = 0.07
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Composite postoperative pulmonary complications during hospital stay (inpatients)
P = 0.19
- Composite postoperative pulmonary complications during hospital stay (inpatients) — Overall PPCs among inpatients
- 22/1,916 (1.1%)
Original publication
Comparison of postoperative oxygenation in children receiving sugammadex versus neostigmine for reversal of neuromuscular blockade: a retrospective cohort study. Can J Anaesth. Published 30 January 2025. doi:10.
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