Perioperative medicine & outcomes
An Updated Systematic Review and Meta-Analysis of Unimodal Prehabilitation with Exercise Intervention to Enhance Postoperative Outcomes in Cancer Surgery
Authors' conclusion
Evidence supports the efficacy of prehabilitation with exercise in reducing postoperative complications and length of hospital stay in patients undergoing lung cancer surgery.
Study context
- Population
- Patients undergoing cancer surgery (genitourinary, lower and upper gastrointestinal, lung)
- Participants
- 2,304 patients · 32 trials
- Comparison
- Prehabilitation vs Control
- Outcome
- Postoperative complications
Methodological detailsrandom-effects meta-analysis, Grading of Recommendations, Assessment, Development, and Evaluations (GRADE), Most included trials had some risk of bias
- Random-effects meta-analysis
- GRADE
- Most included trials had some risk of bias
Pooled result
As reported in the abstract
- Lung resection: complication rates significantly reduced by ≈50% (low-to-moderate quality evidence)
- Other cancer populations: no reduction in postoperative complications
Further pooled results
Hospital LOS
- Lung resection: LOS decreased by 2.5 days
- Other cancer populations: no reduction in LOS
Original publication
An Updated Systematic Review and Meta-Analysis of Unimodal Prehabilitation with Exercise Intervention to Enhance Postoperative Outcomes in Cancer Surgery. Anesth Analg. Published 14 March 2025. doi:10.
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