Analgesic effectiveness of methoxyflurane inhaler during genicular nerve block in knee osteoarthritis: a randomized controlled trial
Authors' conclusion
A methoxyflurane inhaler combined with local anesthesia provided better procedural pain control than local anesthesia alone with no observable differences in adverse effects.
Study context
- Population
- Adults with refractory knee osteoarthritis undergoing genicular nerve block
- Participants
- 42 adults
- Comparison
- Methoxyflurane vs Lidocaine
- Primary endpoint
- Pain score on a 0-10 verbal numerical rating scale (VNRS) during the procedure
- Follow-up
- During the procedure
Primary result
As reported in the abstract
VNRS pain reduction from baseline during the procedure
Methoxyflurane
2
IQR 1–4
Lidocaine
−1
IQR −2–0
P < 0.01
Secondary outcomes
Median
| Outcome | Methoxyflurane | Lidocaine | P value |
|---|---|---|---|
| VNRS reduction over time · during the procedureGreater reduction with methoxyflurane | P = 0.01 | ||
| Sedation score · during the procedureHigher with methoxyflurane | P < 0.01 | ||
| Anxiety (State-Trait Anxiety Inventory score) · immediately postprocedure | 21 (IQR 20–24) | 27 (IQR 23–29) | P = 0.02 |
| Reduction in anxiety level · immediately postprocedureNot significant | 6 (IQR 1–12) | 5 (IQR 0–14) | P = 0.61 |
Behavioral pain scores, hemodynamic parameters, recovery or discharge times
- No differences between the two groups
Safety
Adverse effects
- No differences between the two groups
Original publication
Analgesic effectiveness of methoxyflurane inhaler during genicular nerve block in knee osteoarthritis: a randomized controlled trial. Reg Anesth Pain Med. Published 21 August 2024. doi:10.
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