Regional anaesthesia

Analgesic Effectiveness of Motor-sparing Nerve Blocks for Total Knee Arthroplasty: A Network Meta-analysis

AnesthesiologyPublished Systematic review and network meta-analysis of randomised trials

Authors' conclusion

The results suggest that continuous ACB, but not single-injection ACB and/or single-injection block at the iPACK, provides statistically superior analgesia when added to LIA for total knee arthroplasty compared to LIA alone.

Study context

Population
Patients undergoing total knee arthroplasty
Participants
2,317 patients · 27 studies
Comparison
Single-injection or continuous adductor canal block (ACB) with or without single-injection iPACK block added to local infiltration analgesia (LIA) vs LIA alone
Outcome
Area-under-the-curve pain scores over 24 to 48 h; postoperative function at >24 h
Methodological detailsfrequentist approach
  • Frequentist approach

Pooled result

As reported in the abstract

AUC 24- to 48-h pain: continuous ACB + iPACK highest P-score probability of being most effective

89%

Postoperative function: continuous ACB without iPACK highest P-score probability of being most effective

87%

Original publication

Analgesic Effectiveness of Motor-sparing Nerve Blocks for Total Knee Arthroplasty: A Network Meta-analysis. Anesthesiology. Published 26 June 2023. doi:10.1097/aln.0000000000004667

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