What Is the Role of a Periarticular Injection for Knee Arthroplasty Patients Receiving a Multimodal Analgesia Regimen Incorporating Adductor Canal and Infiltration Between the Popliteal Artery and Capsule of the Knee Blocks? A Randomized Blinded Placebo-Controlled Noninferiority Trial
Primary resultResult — go to the resultDifference 0.3 95% CI −0.9 to 1.5Authors' conclusion
For TKA patients given a comprehensive analgesic protocol, use of saline PAI did not demonstrate noninferiority compared to active PAI.
Study context
- Population
- Patients undergoing primary unilateral total knee arthroplasty (TKA) with a multimodal analgesic protocol (spinal anesthesia, ACB and IPACK blocks)randomised
- Participants
- 94 patients
- Comparison
- Saline PAI vs Active PAI
- Primary endpoint
- NRS pain with ambulation
- Follow-up
- POD 1
Methodological detailsblinded, placebo-controlled, noninferiority
- Blinded
- Placebo-controlled
- Noninferiority
Primary result
As reported in the abstract
Difference
0.3
95% CI −0.9 to 1.5
P = 0.120
Saline PAI vs Active PAI
difference 0.3 (95% CI −0.9 to 1.5); P = 0.120
Secondary outcomes
| Outcome | Saline PAI | Active PAI | P value |
|---|---|---|---|
| Cumulative oral MME through POD 2 | mean 89 (SD 40) mg | mean 73 (SD 52) | P = 0.1 |
Pain scores at rest
- Did not differ significantly among groups
Worst pain, fraction of time in severe pain, pain interference, quality of recovery, satisfaction, LOS, chronic pain, orthopedic outcomes
- No significant differences
Safety
Side-effects (nausea, drowsiness, itching, dizziness)
- No significant differences
Original publication
What Is the Role of a Periarticular Injection for Knee Arthroplasty Patients Receiving a Multimodal Analgesia Regimen Incorporating Adductor Canal and Infiltration Between the Popliteal Artery and Capsule of the Knee Blocks? A Randomized Blinded Placebo-Controlled Noninferiority Trial. Anesth Analg. Published 8 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →