Pain medicine

Single-injection adductor canal block with perineural dexamethasone versus continuous adductor canal catheter for total knee arthroplasty: a randomized controlled trial

Reg Anesth Pain MedPublished Randomised controlled trial

Authors' conclusion

Continuous adductor canal catheter infusion, initiated at the resolution of spinal anesthesia, did not reduce opioid consumption in the 24-48 hour postoperative period following primary TKA within a comprehensive multimodal analgesic regimen including perineural dexamethasone, iPACK block, PAI, oral pain medications, and continuous telemedicine-based pain consultation.

Study context

Population
Patients undergoing primary, unilateral total knee arthroplasty (TKA) with standardized multimodal analgesia (iPACK block, periarticular infiltration (PAI), oral pain medications)
Participants
94 patients
Comparison
Continuous infusion vs Single-injection
Primary endpoint
Opioid consumption
Follow-up
24-48 hour postoperative period
Methodological detailsparticipant-blinded, assessor-blinded
  • Participant-blinded
  • Assessor-blinded

Primary result

As reported in the abstract

95% CI −22.50 to 7.00; P = 0.213

Secondary outcomes

OutcomeSingle-injection
PACU opioid consumption (prespecified secondary outcome)median 15 (IQR 15–30) mg

Patient satisfaction, hospital LOS, functional recovery (exploratory)

No statistically significant differences

Safety

Catheter-associated buckling · all events were transient

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Single-injection adductor canal block with perineural dexamethasone versus continuous adductor canal catheter for total knee arthroplasty: a randomized controlled trial. Reg Anesth Pain Med. Published 4 June 2026. doi:10.1136/rapm-2026-107719

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