Comparison of 10 mL 0.15% vs 20 mL 0.25% bupivacaine boluses for continuous adductor canal block in total knee arthroplasty: a randomized non-inferiority trial
Primary result · Average knee-pain scoreResult — go to the resultMedian treatment difference 0 95% CI −0.45 to 0.45Authors' conclusion
A 10 mL 0.15% bupivacaine bolus in continuous adductor canal block offers comparable average knee-pain relief 6 and 12 hours after total knee arthroplasty to a 20 mL 0.25% bupivacaine bolus.
Study context
- Population
- Patients undergoing total knee arthroplasty receiving continuous adductor canal block (0.15% bupivacaine 5 mL/hour), local infiltration analgesia and IPACK block
- Participants
- 140 patients
- Comparison
- 10/0.15 bupi vs 20/0.25 bupi
- Primary endpoint
- Average knee-pain scores (non-inferiority margin: score difference of 1)
- Follow-up
- 6 and 12 hours postoperatively
Methodological detailsnon-inferiority
- Non-inferiority
Primary result
Average knee-pain score
Median treatment difference
0
95% CI −0.45 to 0.45
By group
20/0.25 bupi
0
median · range 0–1
10/0.15 bupi
0
median · range 0–2
10/0.15 bupi vs 20/0.25 bupi
median treatment difference 0 (95% CI −0.45 to 0.45)
As reported in the abstract
Secondary outcomes
Rest and movement pain scores, morphine consumption, time to first rescue analgesia
- No clinical differences observed in secondary outcomes
Original publication
Comparison of 10 mL 0.15% vs 20 mL 0.25% bupivacaine boluses for continuous adductor canal block in total knee arthroplasty: a randomized non-inferiority trial. Reg Anesth Pain Med. Published 20 May 2025. doi:10.
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