Pediatric anesthesia & critical care
Analgesic use and favourable patient-reported outcome measures after paediatric surgery: an analysis of registry data
Authors' conclusion
The results indicated substantial deficits in the concept, application, and dosing of analgesics in paediatric patients after surgery.
Study context
- Population
- Children after appendectomy or tonsillectomy, 11 European hospitals in PAIN OUT infant
- Participants
- 898 children · 11 hospitals
- Exposure
- Hospitals with favourable vs unfavourable composite PRO results
- Outcome
- Composite PRO measure (pain intensity and pain-related interference)
- Follow-up
- 24 h after surgery
Methodological detailsmulticentre, benchmarking, multinomial regression
- Multicentre
- Benchmarking
- Multinomial regression
Main finding
As reported in the abstract
Full daily doses of non-opioid analgesics (NSAID, paracetamol, metamizole) · first 24 h after surgery
P < 0.001
Observational data: associations, not effects.
Further findings
Factors associated with allocation to Group III vs Group I (multinomial regression)
| OR (95% CI) | ||
|---|---|---|
| Lower number of full daily doses of non-opioid analgesics | 0.22 (0.15–0.31) | |
| Less dexamethasone | 0.49 (0.33–0.71) | |
| Fewer non-opioid analgesics before end of surgery | 0.37 (0.22–0.62) | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Group I | Group III | P value |
|---|---|---|---|
| Intraoperative dexamethasoneGroup I vs Group III | 70.1% | 52.6% | P < 0.001 |
- Factors associated with allocation to Group III vs Group I (multinomial regression): Nagelkerke's R2=0.433
Factors associated with allocation to Group III vs Group I (multinomial regression)
- Higher opioid doses associated with allocation to Group III vs Group I
Original publication
Analgesic use and favourable patient-reported outcome measures after paediatric surgery: an analysis of registry data. Br J Anaesth. Published 5 December 2022. doi:10.
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