Trajectories of pain and opioid use up to one year after surgery: analysis of a European registry
Authors' conclusion
Opioid use was low in patients with CPSP, and more problematic in patients with chronic pain unrelated to surgery.
Study context
- Population
- Mixed surgical patients in European hospitals, PAIN OUT registry
- Participants
- 2,326 patients
- Exposure
- Opioid use and chronic pain before surgery vs 6 and 12 months after surgery; M12 chronic pain categories (chronic postsurgical pain (CPSP), related, unrelated)
- Outcome
- Rate of M12 opioid users
- Follow-up
- 12 months
Methodological detailsmixed surgical cohort, PAIN OUT registry, European
- Mixed surgical cohort
- PAIN OUT registry
- European
Main finding
As reported in the abstract
Opioid use
- Preoperative opioid users
- 5.5%
- Opioid users at M6
- 4.4%
- Opioid users at M12
- 3.5%
- Change over time
- P<0.001
Observational data: associations, not effects.
Further findings
M12 opioid users by M12 chronic pain category (subgroup) · 12 months
New opioid users at M12 (overall 1.1%), by chronic pain category (subgroup) · 12 months
Variable associated with M12 opioid use: preoperative opioid use · 12 months
| Estimated OR (95% CI) | P value | ||
|---|---|---|---|
| Preoperative opioid usePredominant variable | 28.3 (14.1–56.7) | P < 0.001 | |
| 0.050.21520Estimated odds ratio (log scale) |
- New opioid users at M12 (overall 1.1%), by chronic pain category (subgroup) — New opioid users overall
- 1.1%
- M12 opioid users by M12 chronic pain category (subgroup): P<0.001
- New opioid users at M12 (overall 1.1%), by chronic pain category (subgroup): P<0.001
Chronic pain prevalence
- Before surgery
- 41.2%
- At M6
- 41.8%
- At M12
- 34.7%
- Change over time
- P < 0.001
Patient-reported outcomes, M12 opioid users vs non-users · 12 months
- M12 opioid users reported more pain, pain-related physical and affective interference, and needed more opioids than non-users
Original publication
Trajectories of pain and opioid use up to one year after surgery: analysis of a European registry. Br J Anaesth. Published 10 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →