Anterior quadratus lumborum blocks for postoperative pain treatment following intra‐abdominal surgery: A systematic review with meta‐analyses and trial sequential analyses
Pooled result · Cumulative 24-h IV opioid consumptionResult — go to the resultMD −10.42 mg 96.7% CI −14.83 to −6.01Authors' conclusion
The anterior QL block may reduce cumulative 24-h opioid consumption. Reported serious adverse events were few and the anterior QL block may have little to no effect on the number of SAEs, but the evidence was very uncertain.
Study context
- Population
- Adults undergoing any intra-abdominal surgery
- Participants
- 2,418 adults · 35 trials
- Comparison
- Anterior quadratus lumborum (QL) block vs placebo/no block
- Outcome
- Co-primary: cumulative 24-h opioid consumption and serious adverse events
- Follow-up
- 24 h
Methodological detailstrial sequential analysis, GRADE, All trial results assessed as high risk of bias
- Trial sequential analysis
- GRADE
- All trial results assessed as high risk of bias
Pooled result
Cumulative 24-h IV opioid consumption
MD
−10.42 mg
96.7% CI −14.83 to −6.01
P < 0.01
Anterior QL block vs Placebo/no block
MD −10.42 mg (96.7% CI −14.83 to −6.01); P < 0.01
As reported in the abstract
Safety
| Outcome | RR (96.7% CI) | P value | |
|---|---|---|---|
| Serious adverse events (co-primary; 2 trials)Evidence very uncertain · compared to placebo | 1.49 (0.19–11.47) | P = 0.68 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Anterior quadratus lumborum blocks for postoperative pain treatment following intra‐abdominal surgery: A systematic review with meta‐analyses and trial sequential analyses. Acta Anaesthesiol Scand. Published 18 October 2024. doi:10.
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