Antianaerobic Antibiotics, Gut Microbiota, and Sepsis-associated Acute Kidney Injury
Authors' conclusion
Anti-anaerobic antibiotics are associated with increased risk of AKI in sepsis, potentially via modulation of the gut microbiome.
Study context
- Population
- Patients with sepsisretrospective cohort
- Participants
- 12,776 patients
- Comparison
- Early anti-anaerobic antibiotics vs none
- Outcome
- Sepsis-associated AKI incidence
Methodological detailsinstrumental variable analysis (2015-16 piperacillin-tazobactam shortage), murine model
- Instrumental variable analysis (2015-16 piperacillin-tazobactam shortage)
- Murine model
Main finding
As reported in the abstract
Sepsis-associated AKI
Early anti-anaerobic antibiotics independently associated with increased risk of sepsis-associated acute kidney injury (AKI)
61%
95% CI 37%–92%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Antianaerobic Antibiotics, Gut Microbiota, and Sepsis-associated Acute Kidney Injury. Am J Respir Crit Care Med. Published 30 July 2025. doi:10.
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