Perioperative medicine & outcomes
Antiemetic Administration and Its Association with Race: A Retrospective Cohort Study
Main findingResult — go to the resultAdjusted odds ratio 0.82 95% CI 0.81–0.82Authors' conclusion
In a perioperative registry data set, Black versus White patient race was associated with less antiemetic administration, after controlling for all accepted postoperative nausea and vomiting risk factors.
Study context
- Population
- Anesthetic cases in the Multicenter Perioperative Outcomes Group data, 2004 to 2018, 39 institutions in the US and The Netherlands
- Exposure
- Black vs White patient race
- Blackn = 496,456
- Whiten = 3.49 millionreference
- Outcome
- Administration of either ondansetron or dexamethasone
Methodological detailsmulticentre registry, confounder-adjusted multivariable regression, institutions as random effects, Adjusted for Apfel PONV risk factors (sex, smoking history, PONV or motion sickness history, postoperative opioid use) and age
- Multicentre registry
- Confounder-adjusted multivariable regression
- Institutions as random effects
- Adjusted for Apfel PONV risk factors (sex, smoking history, PONV or motion sickness history, postoperative opioid use) and age
Main finding
As reported in the abstract
Adjusted odds ratio
0.82
95% CI 0.81–0.82
P < 0.001
Events by group
Black vs White
aOR 0.82 (95% CI 0.81–0.82); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Black | White | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| Any dexamethasone | 28.3% | 37.0% | 0.78 (0.77–0.78) | P < 0.001 | |
| Any ondansetron | 52.8% | 56.1% | 0.84 (0.84–0.85) | P < 0.001 | |
| Dexamethasone and ondansetron together | 22.7% | 28.9% | 0.78 (0.77–0.79) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Antiemetic Administration and Its Association with Race: A Retrospective Cohort Study. Anesthesiology. Published 9 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →