Antithrombin III Levels and Outcomes Among Patients With Trauma
Authors' conclusion
In this cohort study of patients with trauma, antithrombin III deficiency was associated with greater injury severity, increased hemorrhage, and increased mortality, as well as fewer ventilator-free, hospital-free, and ICU-free days.
Study context
- Population
- Patients with trauma at a level I trauma center, followed from arrival through 6 days from admission
- Participants
- 292 patients
- Exposure
- Antithrombin III deficiency vs no deficiency
- Deficiencyn = 133
- No deficiencyn = 159reference
- Outcome
- Associations between antithrombin III levels and outcomes (ventilator-free days, hospital-free days, intensive care unit (ICU)-free days, hemorrhage, VTE, mortality)
Methodological detailssingle-centre, level I trauma center, Conducted December 2, 2015, to March 24, 2017; analyses September 28, 2023, to June 4, 2024
- Single-centre
- Level I trauma center
- Conducted December 2, 2015, to March 24, 2017; analyses September 28, 2023, to June 4, 2024
Main finding
As reported in the abstract
Ventilator-free days
P = 0.0003
Observational data: associations, not effects.
Further findings
Hospital-free days
P = 1.37 × 10-6
ICU-free days
P = 9.38 × 10-6
Deep vein thrombosis (DVT)
- Antithrombin III deficiency not significantly associated with DVT; patients who developed DVT had a more precipitous, significantly lower decrease in antithrombin III levels
Safety
Progressive intracranial hemorrhage
P = 0.0003
Thrombocytopenia
P = 1.94 × 10-6
Original publication
Antithrombin III Levels and Outcomes Among Patients With Trauma. JAMA Netw Open. Published 1 August 2024. doi:10.
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