Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial
Authors' conclusion
DSI appears promising in critically injured trauma patients who do not allow adequate preoxygenation due to agitation and delirium and require definitive airway on arrival.
Study context
- Population
- Critically injured, agitated and delirious trauma patients requiring definitive airway management on arrival
- Participants
- 200 participants
- Comparison
- Delayed sequence intubation vs rapid sequence intubation
- Primary endpoint
- Incidence of peri-intubation hypoxia
Primary result
As reported in the abstract
Peri-intubation hypoxia
P = 0.001
Secondary outcomes
First-attempt success rate
P = 0.02
Mean SpO2 change from baseline
- Significant improvement from baseline in DSI only
Safety
Hemodynamic instability
- No incidence of hemodynamic instability
Airway-related adverse events
- No statistically significant difference
Original publication
Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial. Anesth Analg. Published 14 April 2023. doi:10.
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