Propofol versus ketamine in rapid sequence intubation in critically ill patients: a prospective, randomized, controlled trial
Primary resultResult — go to the resultMean difference 6.0 95% CI - 0.0 to 11.9Authors' conclusion
Among critically ill patients undergoing RSI, Ketamine resulted in a less pronounced decrease in MAP in the first 10 min compared with propofol, but the difference was not clinically meaningful or sustained.
Study context
- Population
- Critically ill adults (≥ 18 years) requiring rapid sequence intubation (RSI) in two mixed ICUs175 in modified ITT analysis
- Participants
- 207 adults
- Comparison
- Ketamine vs propofol for RSI
- Ketaminen = 91
- Propofoln = 84reference
- Primary endpoint
- Lowest MAP after induction (linear regression adjusted for age, baseline MAP and total vasopressor dose within 10 min)
- Follow-up
- First 10 min after induction
Methodological detailsinvestigator-initiated, open-label, two-centre, October 2021 to October 2023
- Investigator-initiated
- Open-label
- Two-centre
- October 2021 to October 2023
Primary result
As reported in the abstract
Mean difference
6.0
95% CI - 0.0 to 11.9
P = 0.050
By group
Ketamine vs Propofol
mean difference 6.0 (95% CI - 0.0 to 11.9); P = 0.050
Further findings
Cardiovascular collapse
| Outcome | Ketamine | Propofol | OR (95% CI) | |
|---|---|---|---|---|
| Mortality · Day 7 | 33% | 23.8% | 1.38 (0.86–2.24) | |
| Hospital mortality | 60.4% | 50.0% | 1.21 (0.92–1.58) | |
| 0.512Odds ratio (log scale) |
- Cardiovascular collapse: mainly due to an increase in the vasopressor dose within 2 min
Average mean arterial pressure (MAP) difference · first hour
- Average MAP difference over the first hour
- 1.67 (95% CI - 1.98 to 5.31)
Safety
Cardiovascular collapse
- Cardiovascular collapse: mainly due to an increase in the vasopressor dose within 2 min
Original publication
Propofol versus ketamine in rapid sequence intubation in critically ill patients: a prospective, randomized, controlled trial. Intensive Care Med. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →