Arterial Hypotension During Cardiopulmonary Bypass and Postoperative Lung Injury in Patients Undergoing Urgent Surgery for Acute Type A Aortic Dissection: A Propensity Score-matched Retrospective Cohort Study
Main findingResult — go to the resultOdds ratio 3.07 95% CI 1.54–6.15Authors' conclusion
The current findings suggest that both the depth and duration of intraoperative hypotension during CPB are associated with PLI.
Study context
- Population
- Adults undergoing emergency acute type A aortic dissection repair, tertiary academic cardiovascular ICU in France, 2018–2020; refractory low cardiac output syndrome or extracorporeal life support excluded144 after matching
- Participants
- 150 adults
- Exposure
- Hypotension during cardiopulmonary bypass (CPB) vs no hypotension
- Outcome
- Postoperative lung injury (PaO₂/FiO₂ ratio ≤200 mmHg for more than 24 consecutive hours)
- Follow-up
- Within the first 10 postoperative days
Methodological detailssingle-centre, propensity-score matched, sensitivity analyses
- Single-centre
- Propensity-score matched
- Sensitivity analyses
Main finding
As reported in the abstract
Odds ratio
3.07
95% CI 1.54–6.15
P < 0.001
By group
Hypotensive vs Nonhypotensive
OR 3.07 (95% CI 1.54–6.15); P < 0.001
Observational data: associations, not effects.
Further findings
Postoperative lung injury (PLI) by alternative hypotension threshold (sensitivity analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Mean arterial pressure <55 mmHg lasting >10 minutesSensitivity analyses | 2.35 (1.11–4.99) | P = 0.03 | |
| 0.20.5125Odds ratio (log scale) |
- Dose-response association with deeper and longer hypotension
Original publication
Arterial Hypotension During Cardiopulmonary Bypass and Postoperative Lung Injury in Patients Undergoing Urgent Surgery for Acute Type A Aortic Dissection: A Propensity Score-matched Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 12 October 2025. doi:10.
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