Cardiothoracic & vascular anaesthesia
Autologous Platelet-Rich Plasma Decreases Intraoperative Allogeneic Transfusion in Cyanotic Patients Undergoing Cardiac Surgery
Authors' conclusion
In a predominantly redo cohort of patients with CCHD undergoing cardiac surgery, the use of aPRP was associated with reduced intraoperative allogeneic blood and plasma transfusion requirements, and it also effectively preserved hemostatic function in these patients. However, the reduction in allogeneic product use may not be primarily due to the preserved hemostatic function conferred by aPRP but rather to autologous substitution of allogeneic products.
Study context
- Population
- Patients with cyanotic congenital heart disease (CCHD) who underwent cardiac surgery with cardiopulmonary bypass (CPB) between January 2020 and August 2025included, of whom 81 (85.3%) underwent redo operation
- Participants
- 95 patients
- Exposure
- Autologous platelet-rich plasma (aPRP) v control
- Outcome
- Packed red blood cell (PRBC) transfusion rates and PRBC and fresh-frozen plasma (FFP) transfusion volume (original cohort)
Methodological detailspropensity score matching, tertiary university hospital
- Propensity score matching
- Tertiary university hospital
Main finding
As reported in the abstract
- Significantly lower in the aPRP group than the control group
- Original cohort
Observational data: associations, not effects.
Further findings
Intraoperative PRBC transfusion rate · no longer differed significantly · after propensity score matching
P = 0.180
| Outcome | aPRP group | Control group | P value |
|---|---|---|---|
| PRBC transfusion volume, totalSignificantly lower in the aPRP group · after propensity score matching | 0 [0, 0] mL | 0 [0, 400] mL | P = 0.037 |
| PRBC transfusion volume, weight-adjustedSignificantly lower in the aPRP group · after propensity score matching | 0 [0, 0] mL/kg | 0 [0, 15.7] mL/kg | P = 0.045 |
| Intraoperative FFP transfusion requirementsSignificantly reduced in the aPRP group · matched | 200 [0, 600] mL | 600 [400, 1,000] mL | P < 0.05 |
Viscoelastic testing (coagulation and platelet function) · following aPRP administration
- Significantly improved coagulation and platelet function following aPRP administration in the treatment group
Intraoperative blood loss, postoperative allogeneic blood products, 24-hour chest tube drainage, use of coagulation agents, postoperative ventilation time, intensive care unit stay
- No difference observed
Original publication
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