Cardiothoracic & vascular anaesthesia

Pneumothorax rates following cardiac surgery with versus without continuous serratus anterior plane catheters: a secondary analysis of trial data with propensity score matching to a historic cohort

Can J AnaesthPublished secondary analysis of RCT data with propensity score matching to a historic cohort

Authors' conclusion

Our data suggest that SAP catheter use as a part of a randomized trial for cardiac surgery was associated with a higher rate of pneumothorax in trial participants than in a historic cohort of a similar population, though causality is unclear. Differences in monitoring within the trial and the inherent risks in this population may have contributed.

Study context

Population
Patients undergoing cardiac surgery via sternotomy at a single institutionCardiac-SAP trial patients matched 50 · retrospective cohort patients 989
Participants
50 vs 989
Comparison
Pneumothorax rates in patients receiving continuous serratus anterior plane (SAP) catheters in our previous Cardiac-Serratus Anterior Plane (Cardiac-SAP) trial with those in a retrospective institutional database cohort of patients receiving standard care
  • SAP catheter groupn = 50
  • Historic cohortn = 989reference
Methodological details1:20 propensity score matching, retrospective institutional database cohort
  • 1:20 propensity score matching
  • Retrospective institutional database cohort

Primary result

As reported in the abstract

Intensive care unit (ICU) readmissions, length of ventilation, and length of ICU or hospital stay
  • No significant differences

Further findings

Patients who developed a pneumothorax had longer ventilation time and longer hospital stays

Safety

OutcomeSAP catheter groupHistoric cohortOdds ratio (95% CI)P value
PneumothoraxAfter matching12%3%5.3 (2.1–13.6)P < 0.001

Original publication

Pneumothorax rates following cardiac surgery with versus without continuous serratus anterior plane catheters: a secondary analysis of trial data with propensity score matching to a historic cohort. Can J Anaesth. Published 22 October 2026. doi:10.1007/s12630-026-03206-3

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