Cardiothoracic & vascular anaesthesia
Hemoadsorption to prevent acute kidney injury in elective cardiac surgery: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis
Pooled result · Incidence of cardiac surgery-associated acute kidney injury (CSA-AKI)Result — go to the resultRelative risk 0.93 95% CI 0.71–1.21Authors' conclusion
Hemoadsorption during CPB was not associated with a reduction in CSA-AKI or with improvement in secondary clinical outcomes in elective patients undergoing cardiac surgery. However, the accrued sample represented only 48% of the heterogeneity-adjusted required information size (1,491 patients), and the cumulative Z-curve crossed neither the monitoring nor the futility boundary.
Study context
- Population
- Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)six randomized controlled trials (RCTs) included
- Participants
- 798 patients
- Comparison
- Hemoadsorption versus standard care
- Outcome
- Incidence of cardiac surgery-associated acute kidney injury (CSA-AKI)
- Follow-up
- Within 7 days after surgery
Methodological detailsfrequentist approach, prospectively registered protocol
- Frequentist approach
- Prospectively registered protocol
Pooled result
As reported in the abstract
Relative risk
0.93
95% CI 0.71–1.21
P = 0.57
Hemoadsorption vs control
RR 0.93 (95% CI 0.71–1.21); P = 0.57
Further pooled results
Secondary outcomes: interleukin-6, tumor necrosis factor, 28-day mortality, SOFA score, and ICU length of stay
- Hemoadsorption was not associated with significant differences in secondary outcomes
Original publication
Hemoadsorption to prevent acute kidney injury in elective cardiac surgery: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis. Anaesth Crit Care Pain Med. Published 21 October 2026. doi:10.
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