Cardiothoracic & vascular anaesthesia
Correlation of Neuron‐Specific Enolase and S100ß Protein Levels, Inflammatory Cytokines, and Neurological Injury in Children Undergoing Cardiopulmonary Bypass
Authors' conclusion
The positive correlation between NSE, S100ß, inflammatory cytokines, and neurological deficits suggests that the systemic inflammatory response to CPB may contribute to neurological injury and that NSE and S100ß may be useful tools to detect neurological injury following CPB.
Study context
- Population
- Children undergoing cardiac surgery with cardiopulmonary bypass (CPB)children undergoing cardiac surgery with CPB
- Participants
- 50 children
- Exposure
- Neurological insult vs Without neurological deficits
- Neurological insultn = Three
- Outcome
- NSE and S100ß levels after bypass
Main finding
As reported in the abstract
- Neuron-specific enolase (NSE) and S100ß increased significantly following bypass and correlated with increases of IL-6, IL-8, and IL-10
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| NSE levels, patients with vs without neurological deficits · post-CPB periodGreater levels of NSE in patients with neurological insult | P = 0.02 |
| S100ß levels, patients with vs without neurological deficits · 24 h post-CPBGreater levels of S100ß in patients with neurological insult | P = 0.02 |
Correlation with duration of CPB and aortic cross clamp
- Significant positive correlation of NSE and S100ß with duration of CPB, and of S100ß with duration of aortic cross clamp
Neurological insult
- Patients who suffered neurological insult
- Three
Original publication
Correlation of Neuron‐Specific Enolase and S100ß Protein Levels, Inflammatory Cytokines, and Neurological Injury in Children Undergoing Cardiopulmonary Bypass. Paediatr Anaesth. Published 20 October 2026. doi:10.
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