Cardiothoracic & vascular anaesthesia
Predictive value of transcranial color Doppler (TCCD) and regional cerebral oxygen saturation for detecting early postoperative brain injury
Authors' conclusion
The decreased rSO2 and cerebral blood flow levels, aorta occlusion time, and history of atrial fibrillation were independent risk factors for early postoperative brain injury. TCCD and rSO2 could effectively monitor brain metabolism and cerebral blood flow and predict early postoperative brain injury.
Study context
- Population
- Patients undergoing cardiovascular surgery with CPB55 enrolled
- Participants
- 50 patients
- Exposure
- Brain injury vs normal
- Brain injuryn = 20
- Normaln = 30reference
- Outcome
- Early postoperative brain injury (NSE ≥ 16.3 ng/mL); predictive value of TCCD and rSO2
- Follow-up
- 24 h after operation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Decreased rSO2 and cerebral blood flow (TCCD)
| Group | Value | Decreased cerebral blood flow, median (IQR) % |
|---|---|---|
| Brain injury | 27.0 (SD 7.3) % | 44.9 (IQR 37.8-69.2) |
| Normal | 17.5 (SD 6.1) % | 29.1 (IQR 12.0-48.2) |
Value
Brain injury27.0 (SD 7.3) %
Normal17.5 (SD 6.1) %
Decreased cerebral blood flow, median (IQR) %
Brain injury44.9 (IQR 37.8-69.2)
Normal29.1 (IQR 12.0-48.2)
- Brain injury vs Normal: P < 0.001
- Brain injury vs Normal: P = 0.004
- Decreased rSO2, decreased cerebral blood flow, aortic occlusion time and history of AF independent risk factors for early postoperative brain injury (multivariate logistic regression)
- P < 0.05
- ROC best cutoff, decreased rSO2
- 21.4%
- ROC best cutoff, decreased cerebral blood flow
- 37.4%
Observational data: associations, not effects.
Further findings
CPB time
P = 0.047
Aortic occlusion time
P = 0.010
Original publication
Predictive value of TCCD and regional cerebral oxygen saturation for detecting early postoperative brain injury. J Clin Monit Comput. Published 17 May 2024. doi:10.
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