Cardiothoracic & vascular anaesthesia
Ultrasound-Guided Stellate Ganglion Block Regulates Inflammatory Cytokines and Improves Short-Term Outcome after Cardiac Surgery with Cardiopulmonary Bypass: A Randomized Clinical Trial
Authors' conclusion
SGB effectively improves short-term outcomes in patients with cardiac surgery and CPB, possibly through modulating the neuro-endocrine-immune network to normalize sympathetic nervous system activity and stabilize perioperative tumor necrosis factor-α concentration.
Study context
- Population
- Patients aged 18 to 70 scheduled for cardiac surgery with cardiopulmonary bypass (CPB)analysed
- Participants
- 25 vs 25
- Comparison
- Stellate ganglion block (SGB) vs Control
- SGBn = 25
- Controln = 25reference
- Primary endpoint
- Inflammatory cytokine concentration before (T0) and 6 h (T1), 24 h (T2), and 5 days (T3) after the block
Methodological detailsprospective, double-blinded, single-centre
- Prospective
- Double-blinded
- Single-centre
Primary result
As reported in the abstract
TNF-α concentration · 6 and 24 hours after the block
- SGB significantly inhibited elevated TNF-α concentration vs control
- p < 0.05
Secondary outcomes
SIRS 24 hours after surgery
- Significantly reduced with SGB
Immune function (neutrophil and lymphocyte percentage)
- SGB decreased neutrophil percentage at 6 h and increased lymphocyte percentage at 5 days after the block
Safety
Complications: ventricular fibrillation after reperfusion, postoperative delirium, Clavien-Dindo grade III-IV
- Decreased with SGB
Original publication
Ultrasound-Guided Stellate Ganglion Block Regulates Inflammatory Cytokines and Improves Short-Term Outcome after Cardiac Surgery with Cardiopulmonary Bypass: A Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 15 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →